Recently, researchers have described a method that can be used to assess the biological aging process. Related papers were published in "Nature-Communication".
Aging is associated with worsening functional decline and increased risk of chronic diseases. Determining the biological age is very complicated and does not necessarily correspond to the age that changes over time. Various studies use blood markers, DNA methylation and other methods to develop biomarkers and predictors of aging, which are expected to be used clinically to determine anti-aging interventions The effect of the measures.
Timothy Pyrkov and colleagues of Gero PTE in Singapore, using the British biobank and longitudinal human blood count data from a nutrition and health survey, developed a single variable describing biological age, which they called a "dynamic organism status indicator" "(DOSI).
DOSI is related to expected variables such as age, disease, and lifestyle. Researchers say that changes in DOSI can be used as a measure of physiological resilience, indicating the ability to recover from disturbances (such as diseases). The authors found that the change in DOSI increased with age due to the increase in recovery time. They also used the gradual loss of resilience to predict the maximum human life span of about 120 to 150 years. These calculations are consistent with the results of other studies.