Skip to main content

Four non-motor symptoms of Parkinson's

    The core symptom of Parkinson's disease is bradykinesia, which is a slowing and inflexibility of movement in daily activities. Shaking, also known as tremor, is a well-known symptom of Parkinson's disease, but the tremor of Parkinson's disease has its characteristics, that is, it is manifested as resting tremor, which is obvious when still, aggravated by mental stress, relieved when doing voluntary movement, and relieved when sleeping. disappear.

   Most of the symptoms start from one upper extremity, which is manifested as shaking like "rubbing a pill". As the disease worsens, the legs, jaw and head may shake. It should be pointed out that not all shaking is Parkinson's disease, there are some conditions such as physiological tremor, essential tremor, etc., their incidence is much higher than Parkinson's disease.

   Another important motor symptom of Parkinson's disease patients is muscle stiffness, which not only affects the limbs but also the facial expression muscles, so patients with Parkinson's disease will have reduced facial expressions, often called "mask face".

   In addition, there are many motor symptoms, such as abnormal gait, patients with Parkinson's disease often show "small steps" when walking, leaning forward, lack of arm swinging back and forth, and difficulty in stopping. As the disease progresses, patients feel that their feet are stuck to the floor and have difficulty lifting, a condition known as "frozen gait," and often falls due to instability.

   Frequent insomnia or early awakening, urgency to urinate, frequent urination, and frequent urination may be non-motor symptoms of Parkinson's disease. Here are four non-motor symptoms of Parkinson's disease to be wary of, experts say.

   One is "the nose is not working". More than 90% of Parkinson's disease patients have symptoms of hyposmia, and many patients have been found to have hyposmia for many years at the time of consultation.

   The second is "not sleeping well". It is understood that many Parkinson's disease patients have difficulty falling asleep, wake up frequently or early, excessive sleepiness during the day, and may scream, make noise, kick people, and beat people in their sleep, which seriously affects the sleep quality of patients.

   The third is constipation. Patients often develop symptoms of constipation 10 or even 20 years before the onset of symptoms.

   Fourth, anxiety and depression. Anxiety is mainly manifested as generalized anxiety and panic disorder; the incidence of depression is the highest, which can run through the entire course of Parkinson's disease. 


Hebei Xingang Pharmaceutical Co Ltd | Rifamycin API Manufacturer Since 1996

Hebei Xingang Pharmaceutical Co Ltd - Global Leader in Rifamycin API Production

About Hebei Xingang Pharmaceutical

Established in 1996, Hebei Xingang Pharmaceutical Co Ltd is a GMP-certified manufacturer specializing in:

  • Rifamycin biotechnology fermentation
  • Pharmaceutical intermediates & APIs
  • Anti-TB drug production
Hebei Xingang Pharmaceutical GMP Facility

Core Product Portfolio

Rifamycin Series

  • Rifamycin S-Na Salt
  • Rifampicin API
  • Rifapentine

Intermediate Products

  • 3-Formylrifamycin SV
  • Rifamycin S

Quality Certifications

  • Chinese GMP Certification (2004, 2010, 2015)
  • BP/EP/USP Compliance
  • ISO 9001:2015 Certified

Manufacturing Excellence

Advanced Facilities

  • Computer-controlled fermentation systems
  • Isolated production lines
  • Oil-free air compressors

R&D Strength

  • Microbial fermentation lab
  • University collaborations
  • 20+ years strain optimization

Global Presence

Exporting to 30+ countries including:

  • India & Pakistan
  • European Union
  • South America
Hebei Xingang Pharmaceutical Global Distribution

Contact Hebei Xingang Pharmaceutical

No.2 Fuqiang Street, Zhaoyuan Road, Zhao County, Shijiazhuang
Hebei Province, China
Tel: +86-311-8088-9705
Email: info@xgpharm.cn
Home Contact

© Hebei Xingang Pharmaceutical Co Ltd. All rights reserved.