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Eye disease linked to increased dementia risk, study shows

   According to reports, a research paper published in the "British Journal of Ophthalmology" in mid-September showed that people suffering from age-related macular degeneration (AMD, Age-related macular degeneration), cataracts and diabetes-related eye diseases, elderly There is an increased risk of dementia, but no link has been found between glaucoma and Alzheimer's.

  Alzheimer's disease is becoming more and more common, but so far, we still have no effective drugs to prevent or stop its development. At present, relevant research has found that some factors may increase the risk of Alzheimer's disease, such as people with diseases such as weight-related diseases, depression, high blood pressure, diabetes, coronary heart disease and stroke, their risk of Alzheimer's disease will also be rise.

  One of the early manifestations of Alzheimer's disease is heart blindness, also known as imaginative disorder and visual deficit disorder. For example, when you close your eyes, you cannot form specific images in the brain, and this caused visual impairment in the brain. The reduction of the visual signal of the brain will also lead to a reduction in the activation of the central sensory pathway. Over time, the cognitive load on the brain and the risk of impaired thought establishment also increases.

  It has been pointed out that eye disease often accompanies disease in other parts of the body, especially when both are age-related diseases. The link between eye disease and a higher risk of Alzheimer's disease may also be due to the combination of eye disease and diseases in other parts of the body, such as diabetes and cardiovascular disease.

  One of the goals of the study was to investigate which eye diseases, and which diseases in other parts of the body, are associated with an increased risk of dementia.

  In this study, to investigate the link between eye disease and other conditions that accompany dementia, and dementia, researchers surveyed 12,364 adults, ranging in age from 55 to 73, recorded in the UK Biobank. Potential cohort studies and correlation analyses were performed.

  Between 2006 and 2010, the UK Biobank has recorded the health of these 12,364 participants and used it as a baseline. In 2021, the researchers again used sources such as hospital inpatient information, end-of-life information, and self-reports to count the participants' health status, especially whether they had dementia.

  Eye diseases investigated in this study include age-related macular degeneration, cataract, glaucoma, and diabetes-related eye disease .

  Diseases in other parts of the body that accompany the eye disease assessed in the study, including stroke, high blood pressure, diabetes, coronary heart disease and angina.

  After analyzing data from a follow-up survey of these participants for more than 10 years, after removing possible effects of factors such as dietary consumption and lifestyle on the results, the researchers calculated that in addition to the increased risk of glaucoma and dementia In addition to the low correlation between the following, the correlation between the following different types of eye diseases and dementia is as follows: The

  cases of dementia, etc. were counted.

  That is, compared with people without eye disease, people with age-related macular degeneration had a 26% higher risk of dementia, an 11% higher risk of cataracts, and a 61% higher risk of diabetes-related eye disease.

  It was also found that participants with conditions such as diabetes, coronary heart disease, stroke and depression at baseline between 2006 and 2010 also had a higher risk of developing dementia.

  Additionally, although no direct association was found between glaucoma and an increased risk of Alzheimer's disease, glaucoma was found to be associated with an increased risk of vascular dementia.

  And if a person suffers from eye disease as well as other parts of the disease, the risk of developing dementia is also higher.

  People who have both cataracts and the above-mentioned diseases in other parts of the body have a 1.19- to 2.29-fold higher risk of developing dementia than those who do not have this condition; and those who have diabetes-related eye diseases and the above-mentioned diseases in other parts of the body at the same time Compared with other people, the risk of dementia is 1.50 to 3.24 times higher.

  Having age-related macular degeneration at the same time as these other diseases in the body also increases the risk of dementia. In particular, having age-related macular degeneration and diabetes at the same time was associated with the highest risk of dementia, with a hazard ratio of 2.73, with a 95% confidence interval of 1.79-4.17.

  But so far, the reasons for this association between eye disease and dementia have remained largely unknown.

  But the researchers commented that "there are many common risk factors between eye disease and dementia, such as increasing age, lack of education, smoking, and physical inactivity". The World Health Organization (WHO) has also made the following recommendations for reducing the risk of dementia: active physical activity, not smoking, avoiding excessive or harmful alcohol intake, weight control, healthy and reasonable diet, blood pressure & cholesterol and blood sugar levels Maintaining a normal and stable level, etc., these behaviors all have the potential to (help) reduce the risk of dementia.


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